翻訳と辞書 Words near each other ・ B-Ball's Best Kept Secret ・ B-Bender ・ B-Bop's ・ B-box zinc finger ・ B-Boy ・ B-Boy Bouillabaisse ・ B-boy Lilou ・ B-Boy Park ・ B-Boy Records ・ B-boying ・ B-CAS ・ B-cell activating factor ・ B-cell chronic lymphocytic leukemia ・ B-cell CLL/lymphoma ・ B-cell leukemia ・ B-cell linker ・ B-cell lymphoma ・ B-cell maturation antigen ・ B-cell prolymphocytic leukemia ・ B-cell receptor ・ B-Class (football) ・ B-class blimp ・ B-class destroyer (1913) ・ B-class lifeboat ・ B-class Melbourne tram ・ B-class submarine ・ B-Complex ・ B-convex space ・ B-cycle ・ B-Daman Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク B-cell linker ： ウィキペディア英語版 B-cell linker The B-cell linker protein is encoded by the ''BLNK'' gene〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29760 )〕 and is an adaptor protein also known as SLP-65, BASH, and BCA. BLNK is expressed in B cells and macrophages and plays a large role in B cell receptor signalling, in a fashion analogous to the role its paralogue SLP-76 plays in T cell receptor signalling. As it has no known intrinsic enzymatic activity, the function of BLNK is to temporally and spatially coordinate and regulate signalling effectors downstream of the B cell receptor. ==Function== The function of BLNK was first illustrated in BLNK deficient DT40 cells, a chicken B-cell line, which exhibited an abrogated intracellular calcium mobilisation response and impaired activation of MAP kinases p38, JNK, and to a lesser degree ERK upon B-cell receptor (BCR) activation as compared to wild type DT40 cells. In knockout mice, BLNK deficiency results in a partial block in B-cell development, and in humans BLNK deficiency results in a much more profound block in B-cell development. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「B-cell linker」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.